1. What is Personalized Medicine? How will you define that in a few words?
Answer:I would like to cite what was written in Wikipedia regarding Personalized Medicine. It is just one statement but I think everything is in it. Here is the statement from Personalized Medicine Web Page of Wikipedia: Not only is personalized medicine tailoring the right drug, for the right person, at the right time but it also includes evaluating predisposition to disease sometimes decades in advance of its threatened onset.
2. Is the environment necessary in the field of Personalized Medicine?
Answer: Of course. That include not only the area that surrounds you or the places considered unhealthy that you usually loiter upon. Pollution is the enemy of the proper functioning of the genes. What you internalize like the air, water and food affects your health because it could trigger the genes to function normally or abnormally and in the case of the latter in the long run produce a disease. In fact, ISCSPM is very much open for membership by a molecular nutritionist, one who has extensive knowledge of the molecular and cellular functions of a specific food (substance) once it is integrated in the body cells and how it affects genetic functions contributory resulting to the person's physiological phenotype.
Below is part of the Introduction of Isidro Antonio Torte Savillo's theoretical article on "The Overpowering Influence of the Environment to Gene Expression" written in 2002 which may be useful for FAQ#2.
"The earth is similar to a universal biological incubator where all present day organisms are capable of living and reproducing. It is clear that our bodies… and for a meaningful rationale, our cells are subjected to various degrees, though each individual factor may differ from each other but not too far apart, of temperature, pressure, radiation, the stretches of days and nights, and other physical phenomena (e.g. the tilting posture particular to the revolution of the earth and works of the gravitational forces, the sounds of the passing train, the visual perception of blinking lights, etc.) in a daily basis. Much more, other factors, like pollution, diseases, food, traditional components that have been gripped by so many, newly shaped cultures as a result of newer trends in fashion, religion, government, commerce, education or just any belief or talent which has sprouted also nudge our cells. These factors, we see and feel around us. Its integration to our bodies via our senses or through the alimentary canal or other openings in our bodies like skin pores, etc. has brought direct or indirect contact to our most precious property inside our cells , Our Genes."
3. Is Personalized Medicine important throughout the life of a person ?
Answer: I would refer you to the statement I made dated 2005:
Late Expression of Undesirable Phenotypes: Life's Inescapable Havoc (in progress)
"The full blown expression of undesirable phenotypes in adults has been served by physiological hints and signals earlier in life which most have dissuaded or ignored. But these are the basis of future bodily catastrophes. To own a genomic profile with a layman's explanation may help protect the individual with proper physiological and environmental treatments thus lessen suffering and may extend survivality." by Isidro T. Savillo, 8/28/2005
4. Is there any alternative wholesome test* in personalized medicine besides genetic/ genomic/ DNA sequencing?
Answer: I would suggest a thorough sytemic molecular biochemical profile of the individual and ( if it warrants this will include) his/her siblings as well as the parents and relatives in addition to the individual's genetic analyses. This will portray the individual's molecular biochemical pathways existing cellularly leading to the construction of an all organ system involvement in these biochemical pathways. This will also lead to the identification of the expressed genetic and cytoplasmic products and subsequently rooting the molecular fate of these products, qualitatively and quantitatively and their interactions resulting to the person's clinical phenotype. In fact, in this way, treating individuals within the family will be much easier for they more or less need similar specific treatments (medications + proper environmental factors) sharing more or less similar molecular biochemical pathways/patterns unless there are offshoots/birth of new molecular biochemical pathways of rare/different products with different fates as shown in the systemic molecular biochemical pathway constructions and these need special pharmacogenomic (might be exogeneous, a mutated contribution, expressed but dormant in other siblings' genome, etc.) treatments. Omics based molecular and cellular analytical work may help in the construction and composition of these molecular biochemical pathways. By Isidro T. Savillo
*Please donot copy any idea from FAQ ISCSPM without asking permission from the ISCSPM personnel. 03/18/2009.
5. Why is Genetics important to Medicine?
Answer: This could be simply answered by Life's Law that I wrote recently:
"Our Genes develop us to our breath
Likewise, Our Genes decipher us to our death"
by Prof. Isidro A. T. Savillo `04/09/2009
The potentials of our genes are also its limitations. If we do something (or the environment doing something) more to our genes..., we may be in big trouble.